Treatment of Aggressive Behavior in Brain Damage

Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior.

In addition to an action on metabolism, anabolic/androgenic steroids also increase sex drive and mental acuity. If abused, such steroids can cause irritability, impulsive aggression, and signs of major depression [Pearson, H. (2004) Nature 431, 500-501], but the mechanisms that produce these symptoms are unknown. The present study investigates behavioral and neurochemical alterations occurring ...

Brain mechanisms of aggressive behavior: an updated review.

During the 25 years since a motivational systems model was proposed to explain the brain mechanisms of aggressive behavior (D.B. Adams. Brain mechanisms for offense, defense, and submission. Behav. Brain. Sci. 2, (1979a) 200-241) considerable research has been carried out. Updating the model in the light of this research requires several changes. A previous distinction between submission and de...

Deep-brain stimulation for aggressive and disruptive behavior.

OBJECTIVE To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. METHODS With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrec...

Environmental Influences , the Developing Brain , and Aggressive Behavior

Effect of muscimol and picrotoxin injection in am and ac nucleus of amygdala on aggressive behavior

Introduction: Aggressive behavior is a major issue in the field of mental health. Pharmacotherapy is often used for the treatment of violent individuals. A neurochemical system most consistently linked with aggression is the GABAergic system. The aim of the present investigation was to examine the effect of muscimol (GABAA agonist) 250 and 500 ng/rat and picrotoxin (GABAA antagonist) 1.5 and...